A girl dying of leukemia compiles a list of things she'd like to do before passing away. Topping the list is her desire to lose her virginity.

Elderly and a virtual prisoner in her own home due to her concerned staff and daughter Carol, Margaret Thatcher, Britain's first woman prime minister, looks back on her life as she clears out her late husband Denis's clothes for the Oxfam shop. Denis is seen as being her rock as she first enters parliament and then runs for the leadership of the Conservative Party, culminating in her eventual premiereship. Now his ghost joins her to comment on her successes and failures, sometimes to her...